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KMID : 0352419920110010059
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Keimyung Medical Journal
1992 Volume.11 No. 1 p.59 ~ p.71
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α_D_Glucosidase, β-D-Glucosidase and β-D-Glucuronidase Activities in Cholestatic Rat Liver Induced by Common Bile Duct Ligation
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Abstract
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A study was made on the changes of α-D-glucosidase, β-D-glucosidase,activities in cholestatic rat liver.
The lysosomal α-D-and β-D-glucosidase,cytosolic broad-specificity β-D-glucosidase, and total β-D-glucosidase and microsomal β-D-glucosidase activities were determined in the cholestatic rat liver induced by common bile duct ligation over a period of forty two days. The activities of α-D-glucosidase,broad-specificity β-D-glucosidase,and β-D-glucosidase in the serum were measured together with the above determination of hepatic glycosidases.
The activity of lysosomal α-D-glucosidase in the cholestatic rat liver increased strikingly between the seventh and the forth-second days after ligation, and that of the serum strikingly increased between the fourteenth and forth-second days after ligation.
The lysosomal acid β-D-glucosidase activity in the cholestatic rat liver markedly increased between the twenty-eighth and the forth-second days after ligation. But the cytosolic broad-specificity β-D-glucosidase in the cholestatic liver showed a slight increased between the seventh and the forty-second day after ligation, and that of the serum strikingly increased between the first and the forty-second days after ligation.
The total β-D-glucosidase and the microsomal β-D-glucosidase activities in the cholestatic liver in creased considerably between the second and the forty-second days after ligation and β-D-glucosidase activity of serum showed a marked increase between the fourteenth and the forth-second days after ligation.
According to the above results,α-D-glucosidase, β-D-glucosidase, β-D-glucosidase in the liver with cholestasis seem to be increasing activities of enzymes with a seemingly cause of the development of synthesis. Especially, when the cholestasis occurred, the activities of these enzymes of serum are higher than those of the enzymes to leak into the blood in great quantity.
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